- Phase 2 (Actuate-1801 Part 3B) trial topline results meet primary endpoint of improved survival in previously untreated patients with metastatic pancreatic ductal adenocarcinoma (mPDAC)
- Oral presentation at the American Society of Clinical Oncology (ASCO) annual meeting to highlight statistically significant improvement in median overall survival and 1-year survival rate in patients treated with the combination of elraglusib and gemcitabine/nab-paclitaxel (GnP) compared to GnP alone
- Company to host KOL event on May 31, 2025, to review data presented
CHICAGO and FORT WORTH, Texas, May 22, 2025 (GLOBE NEWSWIRE) -- Actuate Therapeutics, Inc. (NASDAQ:ACTU) ("Actuate" or the "Company"), a clinical-stage biopharmaceutical company focused on developing therapies for the treatment of high-impact, difficult-to-treat cancers through the inhibition of glycogen synthase kinase-3 beta (GSK-3β), today announced the online publication of the abstract accepted as an oral presentation at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, to take place May 30-June 3, in Chicago, Illinois.
The oral presentation will highlight topline Phase 2 (Actuate-1801 Part 3B) data of elraglusib in combination with GnP in first-line mPDAC and will be presented by Devalingam Mahalingam, MD, PhD, of Northwestern University Feinberg School of Medicine. The topline data demonstrate clinically meaningful and consistent improvements across primary efficacy measures compared to treatment with GnP alone and reinforce the potential of elraglusib to address key unmet needs in this patient population.
The published abstract describes preliminary results reported in December 2024, demonstrating that treatment with elraglusib in combination with GnP resulted in statistically significant increases in 1-year survival rate and median overall survival versus treatment with GnP alone. The combination treatment also resulted in increased Objective Response Rates (ORR) and Disease Control Rates (DCR) in the elraglusib/GnP combination arm versus the GnP control arm.